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Insulin Resistance Explained

  • Writer: Dr Bret Ellington DACM, CFMP, LAc
    Dr Bret Ellington DACM, CFMP, LAc
  • Nov 4, 2025
  • 3 min read

Updated: May 7

Insulin resistance explained and how it effects mood, cravings and energy

Insulin Resistance Explained: What Is Insulin Resistance?

Insulin resistance is one of the most common and overlooked drivers of fatigue, weight gain, hormone imbalance, inflammation, and long-term metabolic disease. It occurs when cells stop responding efficiently to insulin, forcing the body to produce more of it in order to keep blood sugar under control.


Over time, this can create a cycle of higher insulin, unstable energy, increased fat storage, rising inflammation, and greater strain on the entire hormonal system. Many people live with insulin resistance for years before it is formally recognized. You'll often hear of insulin resistance explained as a condition of diabetes or pre-diabetes. Recognizing these patterns before a PCP declares you as diabetic or pre-diabetic can make a huge impact on your health.


At Inner Balance Functional Medicine, we often see insulin resistance hiding underneath symptoms that people do not automatically connect to blood sugar, such as poor sleep, cravings, low mood, stubborn weight issues, anxiety, fatigue, and irregular cycles.


What are the signs of insulin resistance?

Common signs of insulin resistance include fatigue after meals, sugar cravings, abdominal weight gain, brain fog, mood swings, energy crashes, increased hunger, and difficulty losing weight.


Why Insulin Matters

Insulin is a hormone that helps move glucose from the bloodstream into cells where it can be used for energy. When the body becomes resistant to insulin, the pancreas has to produce more and more of it to do the same job.


Insulin resistance does not only affect blood sugar. It affects:

  • Energy production

  • Fat storage

  • Cravings

  • Inflammation

  • Hormone balance

  • Fertility

  • Sleep

  • Aging


This is why insulin resistance is such an important functional medicine issue. It sits upstream of many chronic symptoms.


What Causes Insulin Resistance?

Insulin resistance usually develops over time, not overnight. Common contributors include:

  • High intake of refined carbohydrates and sugar

  • Chronic stress and elevated cortisol

  • Poor sleep

  • Sedentary lifestyle

  • Inflammation

  • Gut dysfunction

  • Hormone imbalance

  • Long COVID or post-viral inflammation

  • Genetic predisposition


It is often the combination of these factors, rather than one single issue, that creates metabolic breakdown.


If your energy crashes, cravings, or stubborn weight feel impossible to fix, insulin resistance may be a major reason. When you understand the root metabolic pattern, your symptoms start making more sense.


Insulin Resistance and Hormones

Insulin has a powerful effect on other hormones. Elevated insulin can worsen:

  • Cortisol dysregulation

  • Sex hormone imbalance

  • Ovarian dysfunction

  • Testosterone imbalance

  • Inflammation

  • Thyroid sluggishness


This is why insulin resistance often overlaps with fertility issues, fatigue, PMS, weight resistance, and mood symptoms.


Common Symptoms

  • Cravings for sweets or carbs

  • Sleepiness after meals

  • Abdominal weight gain

  • Brain fog

  • Feeling shaky when hungry

  • Irritability

  • Frequent hunger

  • Poor energy

  • Trouble losing weight

  • Waking in the night


Some patients also notice they feel better only temporarily after eating, then crash again later.


Why Standard Care Often Misses It

Many people are told their glucose is normal, so they assume blood sugar is not an issue. But insulin resistance can be developing long before glucose becomes abnormal. That is why it is so important to look deeper than one basic marker.

Functional medicine pays attention to early patterns instead of waiting until disease becomes more obvious.


Functional Medicine Approach to Insulin Resistance

At Inner Balance Functional Medicine, the goal is not simply to lower numbers. It is to improve the body’s metabolic flexibility and reduce the stress burden that is driving the problem.


Support may include:

  • Blood sugar-stabilizing nutrition

  • Protein and fiber balance

  • Stress reduction

  • Sleep support

  • Movement and muscle support

  • Inflammation reduction

  • Gut support

  • Personalized supplementation when appropriate

This creates a more sustainable path than extreme restriction or willpower alone.


Check Out Our Related Blogs:


Telehealth Functional Medicine for Colorado and California

Patients in Colorado and California can access telehealth metabolic support through Inner Balance Functional Medicine, making it easier to identify and address insulin resistance before it progresses.


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